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Mpox vaccine - About the mpox vaccine

You will be offered the Modified Vaccinia Ankara (MVA) vaccine. This vaccine helps protect you against mpox (and smallpox).   

There are two versions of this vaccine – Imvanex, made in Europe, and Jynneos, the US version. They are the same vaccine but come in different packaging. The version you get will depend on what’s available. Both are approved and work well. 

How does the vaccine work?

The MVA vaccine contains a virus which has been modified so that it cannot grow in the human body. This vaccine was developed as a much safer form of the smallpox vaccine used widely in the UK and abroad until the 1970s. 

The MVA vaccine cannot cause or spread smallpox or mpox. 

As mpox is caused by a virus like smallpox, vaccines made to protect against smallpox can help prevent or reduce the risk of severe illness from mpox infection.   

Where can I get my vaccination?

The MVA vaccine is offered through specialist sexual health services to those who are eligible.   

The vaccine is available at the following clinics in Wales, by Health Board:  

Aneurin Bevan University Health Board:   

  • Royal Gwent Hospital  

Betsi Cadwaladr University Health Board:  

Cardiff and Vale University Health Board:   

  • Department of Sexual Health, Cardiff Royal Infirmary  

Cwm Taf Morgannwg University Health Board:  

  • Dewi Sant Hospital, Pontypridd  

Hywel Dda University Health Board:   

  • Penlan Clinic, Carmarthen  

Swansea Bay University Health Board:   

  • Neath Port Talbot Hospital  

For the full list of sexual health services across Wales, visit the NHS 111 Wales website. 

Can I pay for an MVA vaccine privately or at a pharmacy?

No, the MVA vaccination is only available through the NHS to eligible individuals. It is a free vaccination. 

How is the MVA vaccine given?

The vaccine will usually be injected into your upper arm. 

What if I have a fear of needles?

If you have a fear of needles, let the person giving you the vaccine know. They will support you. 

How many doses are needed?

Most people need two doses. The second dose should be given at least 28 days after your first dose. 

If you have previously been vaccinated against smallpox with the old (live) smallpox vaccine, you will only need a single dose of the MVA vaccine. 

Once your course is complete, you do not need any more vaccines to protect you against mpox, unless you have a very weakened immune system and had your last dose more than two years ago. 

Page last reviewed: 25th July 2025