All Wales high dose colistin guideline
The polymyxin antibiotic Colistimethate Sodium (CMS) is indicated for the treatment of serious
infections caused by selected, extensively resistant Gram-negative bacteria (for example; primarily
extensively resistant Pseudomonas, Acinetobacter and Enterobacterales) in patients with limited
treatment options. It is often used in combination with another antibiotic.
CMS is a non-active pro-drug which is converted to the active drug Colistin following intravenous
administration. It is a restricted antibiotic and can only be prescribed after discussion with
Microbiology.
Please note: Nebulised Colistin is also used in the management of chronic respiratory conditions, which are outside the scope of these guidelines. Consult local treatment guidelines for further information.