Live attenuated vaccines
Healthcare professionals working in primary and secondary care should ensure that clinically significant immunosuppression in a patient, including infants born to mothers receiving immunosuppressive treatment, is identified before administration of a live attenuated vaccine.
Some recommended vaccines contain live, attenuated (weakened) organisms, which work by mimicking natural infection. Live attenuated vaccines should not be given to people who are clinically immunosuppressed (either due to drug treatment or underlying illness) because the vaccine strain could replicate excessively and cause an extensive, serious infection.