Antimicrobial dosing in renal impairment
Doses are taken from the Renal Drug Database which may recommend dosing outside the product licence, and are based upon creatinine clearance estimated using the Cockcroft and Gault equation. eGFR may be used as an estimate for creatinine clearance, but the Cockcroft and Gault equation should be used for high risk patients including patients with a BMI 40 kg/m2 , or >75 years of age. Consider using the Cockcroft and Gault equation in the elderly, body builders, amputees, patients with a muscle-wasting disease and vegans. In under or overweight patients, use in collaboration with the antimicrobial guideline ‘dosing in extremes of body weight’.
This guideline will be reviewed every 12 months, however for the most up to date guidance, please refer to the Renal Drug Database.